Study: Renal Function Can Help Predict Short-Term Outcomes in Stroke Patients
According to a recent study, estimated glomerular filtration rate (eGFR) on admission to the hospital is an important predictor of poststroke risk of mortality or discharge disposition .
The study included 232,236 ischemic stroke patients from the Get With The Guidelines—Stoke study. Researchers used the Modification of Diet in Renal Disease study equation to calculate the eGFR, dialysis patients were identified using the International Classification of Diseases, Ninth Revision codes, and adjusted multivariable Cox proportional hazard models were used to determine the independent associations of eGFR with discharge disposition and morality.
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“Of 232,236 patients, 47.3% had an eGFR ≥60, 26.6% an eGFR 45 to 59, 16.8% an eGFR 30 to 44, 5.6% an eGFR 15 to 29, 0.7% an eGFR<15 without dialysis, and 2.8% were receiving dialysis,” the researchers wrote.
Overall, 38.6% of patients were discharged home, and 11.8% died during hospitalization or were discharged to a hospice.
Researchers found that renal dysfunction was independently associated with an increased risk of in-hospital mortality, with the highest rate observed in patients with eGFR less than 15 who were not on dialysis.
Likewise, the results showed that patients with an eGFR 15 to 29, less than 15, or on dialysis had lower odds of being discharged home after an ischemic stroke.
Patients with an eGFR above 60 had greater odds of in-hospital survival poststroke, and to be discharged home.
“eGFR on admission is an important predictor of poststroke short-term outcomes,” the researched concluded.
—Melissa Weiss
Reference:
Husseini NE, Fronarow GC, Smith EE, et al. Renal dysfunction is associated with poststroke discharge disposition and in-hospital mortality: findings from Get With The Guidelines—Stroke [published online December 29, 2016]. Stroke. doi:https://doi.org/10.1161/STROKEAHA.116.014601.