Study: Renal Failure Linked to Dementia
A new meta-analysis showed a modest association between renal failure and dementia, with evidence suggesting that the presence of albuminuria in urine increases a patient’s risk of cognitive impairment and dementia.
In their study, researchers searched Medline, Embase, and Cochrane Database of Systematic Reviews, finding 22 studies. The studies were population-based with 100 or more participants who were 45 years and older, and included 1-year follow up data and dementia or cognitive impairment outcomes.
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Their analysis showed sufficient evidence that linked albuminuria to cognitive impairment and dementia. According to their findings, the presence of albuminuria in urine increased a patient’s risk for dementia or cognitive impairment by 35%.
In addition, researchers found mixed results for glomerular filtration rate. There was tentative support for serum creatinine and creatinine clearance causing cognitive impairment or dementia. Likewise, They found insufficient data linking cystatin C with dementia or cognitive impairment.
Overall, the researchers were able to conclude that albuminuria does increase the risk of dementia or cognitive impairment in patients.
—Melissa Weiss
Reference:
Decker K, Camerino I, van Boxtel MPJ, et al. Dementia risk in renal dysfunction: a systematic review and meta-analysis of prospective studies [published online December 14, 2016]. Neurology. doi:10.1212/WNL.0000000000003482