CVD Risk Is Elevated in Certain CKD, Diabetes Patients
Individuals with chronic kidney disease (CKD) and type 1 diabetes who do not have proliferative diabetic retinopathy (PDR) have a lower risk for cardiovascular disease (CVD), according to a recent study.
For their study, the researchers assessed 762 patients with type 1 diabetes for 50 years or more (Medalists), as well as a replication cohort of 675 participants enrolled in the Finnish Diabetic Nephropathy Study (FinnDiane).
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Medalists participants were evaluated via questionnaire, as well as clinical, ophthalmic, and laboratory studies. The presence of CKD, PDR, and CVD were determined using various protocol to assess patient data. Multivariable logistic regression was used to determine associations of CVD status with CKD and PDR.
Results indicated that CVD prevalence among Medalists participants with CKD without PDR (n = 30) and among those with PRD without CKD (n = 339) were half the prevalence in the group with CKD and PDR (n = 66). The researchers observed an independent association of PDR status with CVD (odds ratio 0.21) among patients with CKD.
They noted that, in the Finnish cohort, there had been a trend toward a lower prevalence of CVD in those with CKD and without PDR (n = 21) compared with those with CKD and PDR (n = 170; 19.1% vs 37.1%).
“Absence of PDR in people with type 1 diabetes and CKD was associated with a decreased prevalence of CVD, suggesting that common protective factors for PDR and CVD may exist,” the researchers concluded.
—Christina Vogt
Reference:
Gordin D, Harjutsalo V, Tinsley L, et al. Differential association of microvascular attributions with cardiovascular disease in patients with long duration of type 1 diabetes [Published online January 31, 2018]. Diabetes Care. https://doi.org/10.2337/dc17-2250.