CKD Risk is Elevated With Impaired Glucose Tolerance

Young individuals with impaired glucose tolerance/impaired fasting glucose (IGT/IFG) are at an elevated risk of developing chronic kidney disease (CKD), according to the results of a recent study.

Although the risk of CKD is known to be higher in patients with diabetes, its risk among younger adults with IGT/IFG has not been established.
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The researchers conducted a retrospective cohort study using data from The Health Improvement Network database involving 40,092 patients aged 18 to 40 with a diagnosis of IGT/IFG.

Overall, the unadjusted incidence rate ratio (IRR) for CKD for IGT/IFG compared with normoglycemia was 4.0, and the adjusted IRR was 2.6. Following the development of type 2 diabetes, the unadjusted IRR was 8.8 and the adjusted IRR was 6.3.

“Our results show that young IGT/IFG subjects are also at higher risk of developing CKD. This risk is modulated by the degree of baseline renal function and glucose tolerance, being higher in those developing type 2 diabetes mellitus.”

—Michael Potts

Reference:

Jadhakhan F, Marshall T, Ryan R, Gill P. Risk of chronic kidney disease in young adults with impaired glucose tolerance/impaired fasting glucose: a retrospective cohort study using electronic primary care records [published online February 26, 2018]. BMC Nephrology. https://doi.org/10.1186/s12882-018-0834-4.