Chronic Kidney Disease Risk Elevated by PPI Use

Use of proton pump inhibitors (PPIs) was associated with a 1.4-fold higher risk of chronic kidney disease (CKD), according to the results of a recent study.

Because PPIs have been shown to potentially be associated with kidney injury, the long-term safety of PPI use is a concern, according to the study authors.
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Using a database from the Taiwan National Health Insurance program, the researchers conducted a population-based case-controlled study involving 16,704 cases of newly diagnosed CKD between 2000 and 2013. The participants were matched with randomly selected controls by sex, age, and comorbidities.

Overall, the odds ratio (OR) for CKD was 1.41 for individuals using PPIs compared with those who had never used PPIs.

“Almost all major types of PPIs present a weak association with increased odds of CKD in cumulative duration and dosage regression analysis,” the researchers noted.

The OR in relation to cumulative duration (per month) of PPI use was 1.02 and the OR in relation to the cumulative dosage (per microgram) of PPIs was 1.23.

—Michael Potts

Reference:

Hung S, Liao K, Hung H, et al. Using proton pump inhibitors correlates with an increased risk of chronic kidney disease: a nationwide database-derived case-controlled study. Family Practice. 2018;35(2):166-171.