Diabetes Patients With Inflammatory Biomarker Have Higher Risk For Heart Failure
The biomarker N-terminal pro-B-type natriuretic peptide (NT-proBNP) can predict the 5-year risk of heart failure (HF) in patients with type 2 diabetes, according to a recent study.
In the Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified Release Controlled Evaluation (ADVANCE) trial, the researchers assessed the individual and combined abilities of several biomarkers to predict the incidence or progression of HF in 3098 patients with type 2 diabetes. The biomarkers that were studied included NT-proBNP, high-sensitivity cardiac troponin T (hs-cTnT), interleukin-6 (IL-6), and hs-CRP.
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After adjusting for major risk factors, results indicated that a higher value of each biomarker significantly increased the risk of HF incidence or progression. The hazard ratios per 1-SD increase were 3.06 for NT-proBNP, 1.50 for hs-cTnT, 1.48 for IL-6, and 1.32 for hs-CRP.
Ultimately, the researchers found that adding NT-proBNP to the model including conventional risk factors had improved its ability to predict the 5-year risk of HF. However, adding hs-cTnT, IL-6, or hs-CRP had not consistently improved the prediction metrics in combination with or when added to NT-proBNP.
“Only NT-proBNP strongly and consistently improved the prediction of heart failure in patients with type 2 diabetes beyond a wide range of clinical risk factors and biomarkers,” the researchers concluded.
—Christina Vogt
Reference:
Ohkuma T, Jun M, Woodward M, et al; ADVANCE Collaborative Group. Cardiac stress and inflammatory markers as predictors of heart failure in patients with type 2 diabetes: the ADVANCE trial. Diabetes Care. 2017;40(9):1203-1209. https://doi.org/10.2337/dc17-0509.