Does Psoriasis Increase IBD Risk?

Psoriasis was associated with an increased risk for inflammatory bowel disease (IBD), according to the findings of a recent study.

“Patients with psoriasis may experience comorbidities involving cardiovascular diseases, chronic kidney disease, uveitis, psychiatric disturbances, and metabolic syndrome,” the researchers stated. “However, the association between psoriasis and IBD has been largely unclear.”

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In the systematic review, the researchers identified 9 studies that assessed the odds or risk of IBD among a total of 7,794,087 participants with psoriasis using MEDLINE, Embase, and Cochrane Central Register of Controlled Trials. They analyzed the relative risk (RR) and odds ratio (OR) of IBD, Crohn disease and ulcerative colitis, separately, and conducted a subgroup analysis on these risks among those with psoriatic arthritis.

The researchers observed significant associations between psoriasis and Crohn disease (OR, 1.70; 95% CI, 1.20-2.40) and ulcerative colitis (OR, 1.75; 95% CI, 1.49-2.05). In addition, psoriasis was associated with an increased risk for Crohn disease (RR, 2.53; 95% CI, 1.65-3.89) and ulcerative colitis (RR, 1.71; 95% CI, 1.55-1.89).

“These findings suggest that psoriasis is significantly associated with IBD,” the researchers concluded. “Gastroenterology consultation may be indicated when patients with psoriasis present with bowel symptoms.”

Reference

Fu Y, Lee C, Chi C. Association of psoriasis with inflammatory bowel disease: A systematic review and meta-analysis [published online October 24, 2018]. JAMA Dermatol. doi:10.1001/jamadermatol.2018.3631