Does Psoriatic Arthritis Increase Diabetes Risk?
Psoriatic arthritis (PsA) increases the risk of developing type 2 diabetes, according to the findings of a recent study.
In the study, the researchers identified 6783 individuals with PsA enrolled in the UK Clinical Practice Research Datalink between 1998 and 2014. They matched individuals with PsA to a general population cohort and psoriasis cohort. The incidence of type 2 diabetes, cerebrovascular disease, ischemic heart disease, and peripheral vascular disease were assessed for individuals with PsA, psoriasis, and the general population, and relative risks were calculated.
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Individuals with PsA had a significantly higher risk for type 2 diabetes compared with the general population and individuals with psoriasis (adjusted relative risk [RR] 1.4, 95% CI 1.15-1.70 and RR 1.53 95% CI 1.19-19.7, respectively). Compared with the general population, the incidence of ischemic heart disease, peripheral vascular disease, and all 3 cardiovascular outcomes combined were significantly higher among those with PsA. However, no significant differences in the risk of any cardiovascular outcome was observed between the PsA and psoriasis cohorts.
“The development of type 2 diabetes in an incident population of PsA is significantly higher than in psoriasis alone or in a general population,” the researchers concluded. “Whereas the increased risk of cardiovascular disease in PsA and psoriasis is similar.”
Reference
Charlton R, Green A, Shaddick G, et al. Risk of type 2 diabetes and cardiovascular disease in an incident cohort of people with psoriatic arthritis: a population-based cohort study [published online September 6, 2018]. Rheumatology. https://doi.org/10.1093/rheumatology/key286