Hypotension in a Man With Acute MI

Patients with right ventricular MI (Table) classically present with an inferior wall STEMI and typical symptoms and signs of an acute MI, and blood pressure that is low-normal initially. After administration of a vasodilator, such as nitroglycerin or morphine(, significant hypotension develops (although on occasion, the patient may be hypotensive on presentation, before vasoactive medication is administered). Patients typically appear ashen and are diaphoretic; the neck veins are distended, and the lung fields are clear of vascular congestion. The ECG usually reveals a STEMI of the inferior and/or lateral wall (Figure 1); additional electrocardiographic imaging shows ST-segment elevation in the right ventricular distribution (Figure 2).

This characteristic clinical picture results from an acute failure of the right ventricle. With dysfunction of the right ventricle, left ventricular filling becomes largely dependent on preload, and the typical vasodilators used in patients with acute coronary syndromes have potent preload-reducing effects. Reduced left ventricular filling causes systemic hypotension, and less effective right-sided output results in jugular venous distention. The lung fields are clear (ie, there is no pulmonary edema) because the contractile dysfunction is proximal to the lungs.

Several findings on the standard 12-lead ECG suggest right ventricular acute MI, including ST-segment elevation in the inferior leads (II, III, and aVF)^3,5 and in the right precordial chest leads, particularly lead V₁ (see Figure 1). In fact, lead V₁ is the only standard lead of the 12-lead ECG that directly images the right ventricle.^6-8

On occasion, coexisting acute MI of the posterior wall of the left ventricle may obscure the ST-segment elevation in lead V₁ that is caused by right ventricular MI; this occurs in patients who have acute inferoposterior MI with right ventricular involvement.^9-11 However, a particular pattern of the relative magnitudes of the ST-segment elevation in the various inferior leads--greater ST-segment elevation in lead III than in the other inferior leads--suggests right ventricular acute MI. This pattern of ST-segment elevation occurs because lead III reflects the activity of the right ventricle more directly than do the other inferior leads.

Use of right precordial leads. Nonstandard electrocardiographic imaging can also be useful when right ventricular MI is suspected. Both additional ECG leads and body surface mapping have demonstrated varying degrees of success as diagnostic aids in this setting. The addition of lead RV₄ to the standard 12-lead ECG provides further objective evidence of right ventricular involvement: right ventricular MI can be diagnosed with 80% to 100% sensitivity if ST-segment elevation of more than 1 mm is seen in this lead.^3,12 All the right-sided leads, RV₁ through RV₆, show evidence of right ventricular MI; however, use of lead RV₄ alone has yielded rates of right ventricular MI diagnosis similar to those obtained when the entire array of right-sided ECG leads was used (see Figure 2).⁴

The ST-segment elevation in the right-sided leads is usually less pronounced than that seen on a standard 12-lead ECG in patients with left ventricular STEMI. This disparity results from the fact that the right ventricle is composed of considerably less muscle than the left ventricle; because there is less myocardium to manifest a current of injury, the ST segment is less elevated.

Body surface mapping. This recently developed--but not yet widely used--electrocardiographic technique involves placing numerous leads on a patient's anterior and posterior chest, thereby enabling more complete visualization of cardiac electrical activity. Output from body surface mapping can be displayed in a 12-lead ECG format, in an 80-lead ECG format, and on color contour maps. The color contour maps can be displayed on a torso image or as flat maps. The body map approach to ECG imaging has increased the diagnosis of right ventricular MI in patients with acute coronary syndrome.¹³

Identifying right ventricular involvement is important because patients with coexisting inferior wall infarction have a large amount of jeopardized myocardium. Consequently, they are at increased risk for life-threatening complications, including high-grade atrioventricular block,³ atrial fibrillation, symptomatic sinus bradycardia, atrial infarction (signaled by PR-segment displacement, elevation, or depression in lead II, III, or aVF), cardiogenic shock, and cardiopulmonary arrest.¹² In fact, the complication rate seen in patients with this type of infarction is similar to that seen in patients with anterior wall acute MI.¹⁰

Aggressive therapy is often warranted to limit adverse events. Mortality and in-hospital complications were significantly reduced in patients with right ventricular acute MI (diagnosed on the basis of ST-segment elevation in lead RV₄) who received fibrinolysis.¹⁴ Also, because nitrate-induced hypotension has been well described in patients with right ventricular MI,¹⁵ ST-segment elevation in lead RV₄ should prompt cautious use of nitrates and other vasodilators as well as judicious administration of crystalloid infusions to avoid systemic hypotension.

In the ECG with right-sided leads (see Figure 2), ST-segment elevation was noted in leads RV₁ through RV₆; these findings are consistent with right ventricular MI in the setting of acute inferior wall MI. Further review of the initial 12-lead ECG revealed disproportionate ST-segment elevation in lead III.

After administration of 600 mL of normal saline, the patient's blood pressure was detectable at 105/60 mm Hg. He was transferred to the cardiac catheterization laboratory, where a proximal right coronary artery lesion with occlusive thrombus was detected and a stent was successfully placed. Hypokinesis of the right ventricle and inferior wall of the left ventricle was also noted. Serum troponin levels were elevated, confirming the diagnosis of acute MI. He had an uneventful recovery; good left ventricular function was restored.