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A Child With a Red Rash
HISTORY
A 7-year-old boy with red, nonpruritic rash that appeared first on the cheeks and then spread to the trunk, extremities, and buttocks. No history of respiratory, GI, or other symptoms in the several weeks before the onset of the rash. Patient is otherwise healthy.
PHYSICAL EXAMINATION
The child is afebrile. A lacy erythematous rash is noted on the trunk, extremities, and buttocks.
Erythema infectiosum—also known as fifth disease—is a benign self-limited exanthematous illness of childhood. The condition was the fifth common childhood exanthem to benamed (after measles, scarlet fever, rubella, and Filatov-Dukes disease [an atypical scarlet fever]).
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1. Adler SP, Koch WC. Parvovirus infections. In: Gershon AA, Hotez PJ, Katz SL, eds. Krugman’s Infectious Diseases of Children. 11th ed. Philadelphia: Mosby;2004:429-441.
2. Cossart YE, Field AM, Cant B, Widdows D. Parvovirus-like particles in human sera. Lancet. 1975;1:72-73.
3. Brown KE. Human parvovirus B19. In: Long SS, Pickering LK, Prober CG, eds. Principles and Practice of Pediatric Infectious Diseases. 2nd ed. New York:Churchill Livingstone; 2003:1101-1104.
4. Young NS, Brown KE. Parvovirus B19. N Engl J Med. 2004;350:586-597.
5. Koch WC. Fifth (human parvovirus) and sixth (herpesvirus 6) diseases. Curr Opin Infect Dis. 2001;14:343-356.
6. Huerta-Brogeras M, Izquierdo JA, Hernanz Hermosa JM, et al. Petechial exanthem in “bathing trunk” distribution caused by parvovirus B19 infection. Pediatr Dermatol. 2005;22:430-433.
7. Sabella C, Goldfarb J. Parvovirus B19 infections. Am Fam Physician. 1999;60:1455-1460.
8. Brown KE, Hibbs JR, Gallinella G, et al. Resistance to parvovirus B19 infectiondue to lack of virus receptor (erythrocyte P antigen). N Engl J Med. 1994;330:1192-1196.
9. Vafaie J, Schwartz RA. Parvovirus B19 infections. Int J Dermatol. 2004;43:747-749.
10. Heegaard ED, Brown KE. Human parvovirus B19. Clin Microbiol Rev.2002;15:485-505.
11. Frydenberg A, Starr M. Slapped cheek disease. How it affects children and pregnant women. Aust Fam Physician. 2003;32:589-592.
12.Weir E. Parvovirus B19 infections: fifth disease and more. CMAJ. 2005;172:743.
13. Leach CT, Jenson HB. Erythema infectiosum (fifth disease). In: Jenson HB,Baltimore RS, eds. Pediatric Infectious Diseases. Principles and Practice. Philadelphia:WB Saunders Company; 2002:325-330.
14. Leung AK, Kao CP. A collage of infectious diseases in children. Consultant For Pediatricians. 2004;3:482-487.
15. Cherry JD. Erythema infectiosum. In: Feigin RD, ed. Textbook of Pediatric Infectious Diseases. 5th ed. Philadelphia: Saunders; 2004:1799-1809.
16. Mancini A. Erythema infectiosum (fifth disease). In: Schachner LA, Hansen RC, eds. Pediatric Dermatology. 3rd ed. New York: Mosby; 2003:1064-1066.
17. Stiefel L. Erythema infectiosum (fifth disease). Pediatr Rev. 1995;16:474-475.
18. Kellermayer R, Faden H, Grossi M. Clinical presentation of parvovirus B19 infection in children with aplastic crisis. Pediatr Infect Dis J. 2003;22:1100-1101.
19. Inoue S, Kinra NK, Mukkamala SR, Gordon R. Parvovirus B-19 infection:aplastic crisis, erythema infectiosum and idiopathic thrombocytopenic purpura. Pediatr Infect Dis J. 1991;10:251-253.
20. Muir K, Todd WT, Watson WH, Fitzsimons E. Viral-associated haemophagocytosis with parvovirus-B19-related pancytopenia. Lancet. 1992;339:1139-1140.
21. Mustafa MM, McClain KL. Diverse hematologic effects of parvovirus B19 infection. Pediatr Clin North Am. 1996;43:809-821.
22. Robson WL, Leung AK. Henoch-Schönlein purpura. Adv Pediatr. 1994;41:163-194.
23. Carrascosa JM, Just M, Ribera M, Ferrandiz C. Papular acrodermatitis of childhood related to poxvirus and parvovirus B19 infection. Cutis. 1998;61:265-267.
24. Grilli R, Izquierdo MJ, Farina MC, et al. Papular-purpuric “gloves and socks” syndrome: polymerase chain reaction demonstration of parvovirus B19 DNA in cutaneous lesions and sera. J Am Acad Dermatol. 1999;41:793-796.
25. Jacobson SK, Daly JS, Thorne GM, McIntosh K. Chronic parvovirus B19 infection resulting in chronic fatigue syndrome: case history and review. Clin Infect Dis. 1997;24:1048-1051.
26. Minohara Y, Koitabashi Y, Kato T, Nakajima N. A case of Guillain-Barré syndrome associated with human parvovirus B19 infection. J Infect. 1998;36:327-328.
27. Nigro G, Bastianon V, Colloridi V, Ventriglia F, et al. Human parvovirus B19 infection in infancy associated with acute and chronic lymphocytic myocarditis and high cytokine levels: report of 3 cases and review. Clin Infect Dis. 2000;1:65-69.
28. Sokal EM, Melchior M, Cornu C, et al. Acute parvovirus B19 infection associated with fulminant hepatitis of favourable prognosis in young children. Lancet. 1998;352:1739-1741.
29. Takeda S, Takaeda C, Takazakura E, Haratake J. Renal involvement induced by human parvovirus B19 infection. Nephron. 2001;89:280-285.
30. Kinney JS, Anderson LJ, Farrar J, Strikas RA. Risk of adverse outcomes of pregnancy after human parvovirus B19 infection. J Infect Dis. 1988;157:663-667.
31. Xu J, Raff T, Muallem N, Neubert AG. Hydrops fetalis secondary to parvovirus B19 infections. J Am Board Fam Pract. 2003;16:63-68.
32. Sohan K, Carroll S, Byrne D, et al. Parvovirus as a differential diagnosis of hydrops fetalis in the first trimester. Fetal Diagn Ther. 2000;15:234-236.
33. Miller E, Fairley CK, Cohen BJ, Seng C. Immediate and long term outcome of human parvovirus B19 infection in pregnancy. Br J Obstet Gynaecol. 1998;105:174-178.
34. Silver MM, Hellmann J, Zielenska M, et al. Anemia, blueberry-muffin rash, and hepatomegaly in a newborn infant. J Pediatr. 1996;128:579-586.